Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia.
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منابع مشابه
Indomethacin Prevents Impaired Perfusion of the Dog's Brain after Global Ischemia
Compression ischemia of the central nenous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by "C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by p...
متن کاملIndomethacin prevents impaired perfusion of the dogs's brain after global ischemia.
Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by...
متن کاملReduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia/ reperfusion in a rat model
Background: It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. Recently, it is observed that pentoxifylline has a neuroprotective effect. This study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the...
متن کاملRegional brain PO2 after global ischemia in monkeys: evidence for regional differences in critical perfusion pressures.
We measured brain tissue Po2 in the frontal and occipital cortices, mid-brain and basal ganglia in monkeys for up to 5 hours after 16 min global brain ischemia to gain some insight into those factors responsible for the selective vulnerability of the brain to ischemic anoxia. Brain tissue Po2 measurements were made with gold microelectrodes with tip diameters of 5 to 10 nm. Reoxygenation of the...
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ژورنال
عنوان ژورنال: Stroke
سال: 1978
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.9.6.591